Not known Details About Homeopaty

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Homeopaty and all the things about this

Historical context

Homeopaths claim that Hippocrates may have originated homeopathy around 400 BC, when he prescribed a small dose of mandrake root to treat mania, knowing it produces mania in much larger doses.[31] In the 16th century, the pioneer of pharmacology Paracelsus declared that small doses of "what makes a man ill also cures him".[32] Samuel Hahnemann (1755–1843) gave homeopathy its name and expanded its principles in the late 18th century.

In the late 18th and 19th centuries, mainstream medicine used methods like bloodletting and purging, and administered complex mixtures, such as Venice treacle, which was made from 64 substances including opium, myrrh, and viper's flesh.[33] These treatments often worsened symptoms and sometimes proved fatal.[34][35] Hahnemann rejected these practices – which had been extolled for centuries[36] – as irrational and inadvisable;[37] instead, he advocated the use of single drugs at lower doses and promoted an immaterial, vitalistic view of how living organisms function, believing that diseases have spiritual, as well as physical causes.[38]
Hahnemann's concept
See also: Samuel Hahnemann
Samuel Hahnemann Monument, Washington D.C. with "Similia Similibus Curentur" - Like cures Like.

The term "homeopathy" was coined by Hahnemann and first appeared in print in 1807.[39]

Hahnemann conceived of homeopathy while translating a medical treatise by the Scottish physician and chemist William Cullen into German. Being sceptical of Cullen's theory concerning cinchona's use for curing malaria, Hahnemann ingested some bark specifically to investigate what would happen. He experienced fever, shivering and joint pain: symptoms similar to those of malaria itself. From this, Hahnemann came to believe that all effective drugs produce symptoms in healthy individuals similar to those of the diseases that they treat, in accord with the "law of similars" that had been proposed by ancient physicians.[40] An account of the effects of eating cinchona bark noted by Oliver Wendell Holmes, and published in 1861, failed to reproduce the symptoms Hahnemann reported.[41]:128 Hahnemann's law of similars is a postulate rather than a scientific law.[42] This led to the name "homeopathy", which comes from the Greek: ὅμοιος hómoios, "-like" and πάθος páthos, "suffering".

Subsequent scientific work showed that cinchona cures malaria because it contains quinine, which kills the Plasmodium falciparum parasite that causes the disease; the mechanism of action is unrelated to Hahnemann's ideas.[43]

Hahnemann began to test what effects substances produced in humans, a procedure that would later become known as "homeopathic proving". These tests required subjects to test the effects of ingesting substances by clearly recording all of their symptoms as well as the ancillary conditions under which they appeared.[44] He published a collection of provings in 1805, and a second collection of 65 preparations appeared in his book, Materia Medica Pura, in 1810.[45]

Because Hahnemann believed that large doses of drugs that caused similar symptoms would only aggravate illness, he advocated extreme dilutions of the substances; he devised a technique for making dilutions that he believed would preserve a substance's therapeutic properties while removing its harmful effects.[10] Hahnemann believed that this process aroused and enhanced "the spirit-like medicinal powers of the crude substances".[46] He gathered and published a complete overview of his new medical system in his 1810 book, The Organon of the Healing Art, whose 6th edition, published in 1921, is still used by homeopaths today.[47]
Miasms and disease
A homeopathic preparation made from marsh tea: the "15C" dilution shown here means the original solution was diluted to 1/1030 of its original strength. Given that there are many orders of magnitude fewer than 1030 molecules in the small sample, the likelihood that it contains even one molecule of the original herb is extremely low.

In the Organon, Hahnemann introduced the concept of "miasms" as "infectious principles" underlying chronic disease.[48] Hahnemann associated each miasm with specific diseases, and thought that initial exposure to miasms causes local symptoms, such as skin or venereal diseases. If, however, these symptoms were suppressed by medication, the cause went deeper and began to manifest itself as diseases of the internal organs.[49] Homeopathy maintains that treating diseases by directly alleviating their symptoms, as is sometimes done in conventional medicine, is ineffective because all "disease can generally be traced to some latent, deep-seated, underlying chronic, or inherited tendency".[50] The underlying imputed miasm still remains, and deep-seated ailments can be corrected only by removing the deeper disturbance of the vital force.[51]

Hahnemann's hypotheses for the direct or remote cause of all chronic diseases (miasms) originally presented only three, psora (the itch), syphilis (venereal disease) or sycosis (fig-wart disease).[52] Of these three the most important was psora (Greek for "itch"), described as being related to any itching diseases of the skin, supposed to be derived from suppressed scabies, and claimed to be the foundation of many further disease conditions. Hahnemann believed psora to be the cause of such diseases as epilepsy, cancer, jaundice, deafness, and cataracts.[53] Since Hahnemann's time, other miasms have been proposed, some replacing one or more of psora's proposed functions, including tuberculosis and cancer miasms.[49]

The law of susceptibility implies that a negative state of mind can attract hypothetical disease entities called "miasms" to invade the body and produce symptoms of diseases.[54] Hahnemann rejected the notion of a disease as a separate thing or invading entity, and insisted it was always part of the "living whole".[55] Hahnemann coined the expression "allopathic medicine", which was used to pejoratively refer to traditional Western medicine.[56]

Hahnemann's miasm theory remains disputed and controversial within homeopathy even in modern times. The theory of miasms has been criticized as an explanation developed by Hahnemann to preserve the system of homeopathy in the face of treatment failures, and for being inadequate to cover the many hundreds of sorts of diseases, as well as for failing to explain disease predispositions, as well as genetics, environmental factors, and the unique disease history of each patient.[57]:148–9
19th century: rise to popularity and early criticism

Homeopathy achieved its greatest popularity in the 19th century. It was introduced to the United States in 1825 by Hans Birch Gram, a student of Hahnemann.[58] The first homeopathic school in the US opened in 1835, and in 1844, the first US national medical association, the American Institute of Homeopathy, was established. Throughout the 19th century, dozens of homeopathic institutions appeared in Europe and the United States,[59] and by 1900, there were 22 homeopathic colleges and 15,000 practitioners in the United States.[60] Because medical practice of the time relied on ineffective and often dangerous treatments, patients of homeopaths often had better outcomes than those of the doctors of the time.[61] Homeopathic preparations, even if ineffective, would almost surely cause no harm, making the users of homeopathic preparations less likely to be killed by the treatment that was supposed to be helping them.[47] The relative success of homeopathy in the 19th century may have led to the abandonment of the ineffective and harmful treatments of bloodletting and purging and to have begun the move towards more effective, science-based medicine.[35] One reason for the growing popularity of homeopathy was its apparent success in treating people suffering from infectious disease epidemics.[62] During 19th-century epidemics of diseases such as cholera, death rates in homeopathic hospitals were often lower than in conventional hospitals, where the treatments used at the time were often harmful and did little or nothing to combat the diseases.[63]

From its inception, however, homeopathy was criticized by mainstream science. Sir John Forbes, physician to Queen Victoria, said in 1843 that the extremely small doses of homeopathy were regularly derided as useless, "an outrage to human reason".[64] James Young Simpson said in 1853 of the highly diluted drugs: "No poison, however strong or powerful, the billionth or decillionth of which would in the least degree affect a man or harm a fly."[65] 19th-century American physician and author Oliver Wendell Holmes, Sr. was also a vocal critic of homeopathy and published an essay in 1842 entitled Homœopathy and Its Kindred Delusions.[41] The members of the French Homeopathic Society observed in 1867 that some leading homeopathists of Europe not only were abandoning the practice of administering infinitesimal doses but were also no longer defending it.[66] The last school in the US exclusively teaching homeopathy closed in 1920.[47]
Revival in the 20th century
Main article: Regulation and prevalence of homeopathy

According to Paul Ulrich Unschuld, the Nazi regime in Germany was fascinated by homeopathy, and spent large sums of money on researching its mechanisms, but without gaining a positive result. Unschuld further argues that homeopathy never subsequently took root in the United States, but remained more deeply established in European thinking.[67] In the United States, the Food, Drug, and Cosmetic Act of 1938 (sponsored by Royal Copeland, a Senator from New York and homeopathic physician) recognized homeopathic preparations as drugs. In the 1950s, there were only 75 pure homeopaths practising in the U.S.[68] However, by the mid to late 1970s, homeopathy made a significant comeback and sales of some homeopathic companies increased tenfold.[69] Some homeopaths give credit for the revival to Greek homeopath George Vithoulkas, who performed a "great deal of research to update the scenarios and refine the theories and practice of homeopathy", beginning in the 1970s,[70][71] but Ernst and Singh consider it to be linked to the rise of the New Age movement.[36] Whichever is correct, mainstream pharmacy chains recognized the business potential of selling homeopathic preparations.[72] The Food and Drug Administration held a hearing April 20 and 21, 2015, requesting public comment on regulation of homeopathic drugs.[73] The FDA cited the growth of sales of over-the-counter homeopathic medicines, which was $2.7 billion for 2007.[74]

Bruce Hood has argued that the increased popularity of homeopathy in recent times may be due to the comparatively long consultations practitioners are willing to give their patients, and to an irrational preference for "natural" products, which people think are the basis of homeopathic preparations.[75]
Preparations and treatment
See also: List of homeopathic preparations
Homeopathic preparation Rhus toxicodendron, derived from poison ivy.
a preparation made from D dilutions of dangerous materials like botulism, E-coli, thymus gland of unspecified origin, pneumonia, pseudomona, proteus, salmonella, scarlet fever, staph, strep and tuberculosis bacteria. Ethanol is listed as being redundantly diluted in alcohol.

Homeopathic preparations are referred to as "homeopathics"[11] or "remedies". Practitioners rely on two types of reference when prescribing: materia medica and repertories. A homeopathic materia medica is a collection of "drug pictures", organized alphabetically. These entries describe the symptom patterns associated with individual preparations. A homeopathic repertory is an index of disease symptoms that lists preparations associated with specific symptoms. In both cases different compilers may dispute particular inclusions.[76] The first symptomatic homeopathic materia medica was arranged by Hahnemann. The first homeopathic repertory was Georg Jahr's Symptomenkodex, published in German in 1835, and translated into English as the Repertory to the more Characteristic Symptoms of Materia Medica by Constantine Hering in 1838. This version was less focused on disease categories and would be the forerunner to later works by James Tyler Kent.[77][78] Repertories, in particular, may be very large.

Homeopathy uses animal, plant, mineral, and synthetic substances in its preparations, generally referring to them using Latin or faux-Latin names. Examples include arsenicum album (arsenic oxide), natrum muriaticum (sodium chloride or table salt), Lachesis muta (the venom of the bushmaster snake), opium, and thyroidinum (thyroid hormone).

Some homeopaths use so-called "nosodes" (from the Greek nosos, disease) made from diseased or pathological products such as fecal, urinary, and respiratory discharges, blood, and tissue.[77] Conversely, preparations made from "healthy" specimens are called "sarcodes".

Some modern homeopaths use preparations they call "imponderables" because they do not originate from a substance but some other phenomenon presumed to have been "captured" by alcohol or lactose. Examples include X-rays[79] and sunlight.[80]

Other minority practices include paper preparations, where the substance and dilution are written on pieces of paper and either pinned to the patients' clothing, put in their pockets, or placed under glasses of water that are then given to the patients, and the use of radionics to manufacture preparations. Such practices have been strongly criticized by classical homeopaths as unfounded, speculative, and verging upon magic and superstition.[81][82]
Mortar and pestle used for grinding insoluble solids, such as platinum, into homeopathic preparations

Hahnemann found that undiluted doses caused reactions, sometimes dangerous ones, so specified that preparations be given at the lowest possible dose. He found that this reduced potency as well as side-effects, but formed the view that vigorous shaking and striking on an elastic surface – a process he termed Schütteln, translated as succussion – nullified this.[83] A common explanation for his settling on this process is said to be that he found preparations subjected to agitation in transit, such as in saddle bags or in a carriage, were more "potent".[57]:16 Hahnemann had a saddle-maker construct a special wooden striking board covered in leather on one side and stuffed with horsehair.[84]:31 Insoluble solids, such as granite, diamond, and platinum, are diluted by grinding them with lactose ("trituration").[57]:23

The process of dilution and succussion is termed "dynamization" or "potentization" by homeopaths.[9][85] In industrial manufacture this may be done by machine.

Serial dilution is achieved by taking an amount of the mixture and adding solvent, but the "Korsakovian" method may also be used, whereby the vessel in which the preparations are manufactured is emptied, refilled with solvent, and the volume of fluid adhering to the walls of the vessel is deemed sufficient for the new batch.[57]:270 The Korsakovian method is sometimes referred to as K on the label of a homeopathic preparation, e.g. 200CK is a 200C preparation made using the Korsakovian method.[86][87]

Fluxion and radionics methods of preparation do not require succussion.[57]:171 There are differences of opinion on the number and force of strikes, and some practitioners dispute the need for succussion at all while others reject the Korsakovian and other non-classical preparations. There are no laboratory assays and the importance and techniques for succussion cannot be determined with any certainty from the literature.[57]:67–69
Main article: Homeopathic dilutions

Three main logarithmic potency scales are in regular use in homeopathy. Hahnemann created the "centesimal" or "C scale", diluting a substance by a factor of 100 at each stage. The centesimal scale was favoured by Hahnemann for most of his life.

A 2C dilution requires a substance to be diluted to one part in 100, and then some of that diluted solution diluted by a further factor of 100.

This works out to one part of the original substance in 10,000 parts of the solution.[88] A 6C dilution repeats this process six times, ending up with the original substance diluted by a factor of 100−6=10−12 (one part in one trillion or 1/1,000,000,000,000). Higher dilutions follow the same pattern.

In homeopathy, a solution that is more dilute is described as having a higher "potency", and more dilute substances are considered by homeopaths to be stronger and deeper-acting.[89] The end product is often so diluted as to be indistinguishable from the diluent (pure water, sugar or alcohol).[10][90][91] There is also a decimal potency scale (notated as "X" or "D") in which the preparation is diluted by a factor of 10 at each stage.[92]

Hahnemann advocated 30C dilutions for most purposes (that is, dilution by a factor of 1060).[9] Hahnemann regularly used potencies up to 300C but opined that "there must be a limit to the matter, it cannot go on indefinitely".[44]:322

In Hahnemann's time, it was reasonable to assume the preparations could be diluted indefinitely, as the concept of the atom or molecule as the smallest possible unit of a chemical substance was just beginning to be recognized.

The greatest dilution reasonably likely to contain even one molecule of the original substance is 12C.[93]
This bottle is labelled Arnica montana (wolf's bane) D6, i.e. the nominal dilution is one part in a million (10-6).

Critics and advocates of homeopathy alike commonly attempt to illustrate the dilutions involved in homeopathy with analogies.[94] Hahnemann is reported to have joked that a suitable procedure to deal with an epidemic would be to empty a bottle of poison into Lake Geneva, if it could be succussed 60 times.[95][96] Another example given by a critic of homeopathy states that a 12C solution is equivalent to a "pinch of salt in both the North and South Atlantic Oceans",[95][96] which is approximately correct.[97] One-third of a drop of some original substance diluted into all the water on earth would produce a preparation with a concentration of about 13C.[94][98][99] A popular homeopathic treatment for the flu is a 200C dilution of duck liver, marketed under the name Oscillococcinum. As there are only about 1080 atoms in the entire observable universe, a dilution of one molecule in the observable universe would be about 40C. Oscillococcinum would thus require 10320 more universes to simply have one molecule in the final substance.[100] The high dilutions characteristically used are often considered to be the most controversial and implausible aspect of homeopathy.[101]

Not all homeopaths advocate high dilutions. Preparations at concentrations below 4X are considered an important part of homeopathic heritage.[102] Many of the early homeopaths were originally doctors and generally used lower dilutions such as "3X" or "6X", rarely going beyond "12X". The split between lower and higher dilutions followed ideological lines. Those favouring low dilutions stressed pathology and a stronger link to conventional medicine, while those favouring high dilutions emphasized vital force, miasms and a spiritual interpretation of disease.[103][104] Some products with such relatively lower dilutions continue to be sold, but like their counterparts, they have not been conclusively demonstrated to have any effect beyond that of a placebo.[105][106]

A homeopathic "proving" is the method by which the profile of a homeopathic preparation is determined.[107]

At first Hahnemann used undiluted doses for provings, but he later advocated provings with preparations at a 30C dilution,[9] and most modern provings are carried out using ultra-dilute preparations in which it is highly unlikely that any of the original molecules remain.[108] During the proving process, Hahnemann administered preparations to healthy volunteers, and the resulting symptoms were compiled by observers into a "drug picture".

The volunteers were observed for months at a time and made to keep extensive journals detailing all of their symptoms at specific times throughout the day. They were forbidden from consuming coffee, tea, spices, or wine for the duration of the experiment; playing chess was also prohibited because Hahnemann considered it to be "too exciting", though they were allowed to drink beer and encouraged to exercise in moderation.[109]

After the experiments were over, Hahnemann made the volunteers take an oath swearing that what they reported in their journals was the truth, at which time he would interrogate them extensively concerning their symptoms.

Provings are claimed to have been important in the development of the clinical trial, due to their early use of simple control groups, systematic and quantitative procedures, and some of the first application of statistics in medicine.[110] The lengthy records of self-experimentation by homeopaths have occasionally proven useful in the development of modern drugs: For example, evidence that nitroglycerin might be useful as a treatment for angina was discovered by looking through homeopathic provings, though homeopaths themselves never used it for that purpose at that time.[111] The first recorded provings were published by Hahnemann in his 1796 Essay on a New Principle.[112] His Fragmenta de Viribus (1805)[113] contained the results of 27 provings, and his 1810 Materia Medica Pura contained 65.[114] For James Tyler Kent's 1905 Lectures on Homoeopathic Materia Medica, 217 preparations underwent provings and newer substances are continually added to contemporary versions.

Though the proving process has superficial similarities with clinical trials, it is fundamentally different in that the process is subjective, not blinded, and modern provings are unlikely to use pharmacologically active levels of the substance under proving.[115] As early as 1842, Holmes noted the provings were impossibly vague, and the purported effect was not repeatable among different subjects.[41]
See also: Nocebo
Homeopathic repertory by James Tyler Kent

Homeopaths generally begin with detailed examinations of their patients' histories, including questions regarding their physical, mental and emotional states, their life circumstances and any physical or emotional illnesses. The homeopath then attempts to translate this information into a complex formula of mental and physical symptoms, including likes, dislikes, innate predispositions and even body type.[116]

From these symptoms, the homeopath chooses how to treat the patient using materia medica and repertories. In classical homeopathy, the practitioner attempts to match a single preparation to the totality of symptoms (the simlilum), while "clinical homeopathy" involves combinations of preparations based on the various symptoms of an illness.[70]
Pills and active ingredients
Homeopathic pills, homeopathic preparation oscillococcinum

Homeopathic pills are made from an inert substance (often sugars, typically lactose), upon which a drop of liquid homeopathic preparation is placed and allowed to evaporate.[117][118]

The process of homeopathic dilution results in no objectively detectable active ingredient in most cases, but some preparations (e.g. calendula and arnica creams) do contain pharmacologically active doses. One product, Zicam Cold Remedy, which was marketed as an "unapproved homeopathic" product,[119] contains two ingredients that are only "slightly" diluted: zinc acetate (2X = 1/100 dilution) and zinc gluconate (1X = 1/10 dilution),[119] which means both are present in a biologically active concentration strong enough to have caused some people to lose their sense of smell,[120] a condition termed anosmia. Zicam also listed several normal homeopathic potencies as "inactive ingredients", including galphimia glauca,[121] histamine dihydrochloride (homeopathic name, histaminum hydrochloricum),[122] luffa operculata,[123] and sulfur.
Related and minority treatments and practices

Isopathy is a therapy derived from homeopathy, invented by Johann Joseph Wilhelm Lux in the 1830s. Isopathy differs from homeopathy in general in that the preparations, known as "nosodes", are made up either from things that cause the disease or from products of the disease, such as pus.[77][124] Many so-called "homeopathic vaccines" are a form of isopathy.[125]
Flower preparations

Flower preparations can be produced by placing flowers in water and exposing them to sunlight. The most famous of these are the Bach flower remedies, which were developed by the physician and homeopath Edward Bach. Although the proponents of these preparations share homeopathy's vitalist world-view and the preparations are claimed to act through the same hypothetical "vital force" as homeopathy, the method of preparation is different. Bach flower preparations are manufactured in allegedly "gentler" ways such as placing flowers in bowls of sunlit water, and the preparations are not succussed.[126] There is no convincing scientific or clinical evidence for flower preparations being effective.[127]
Veterinary use

The idea of using homeopathy as a treatment for other animals termed "veterinary homeopathy", dates back to the inception of homeopathy; Hahnemann himself wrote and spoke of the use of homeopathy in animals other than humans.[128] The FDA has not approved homeopathic products as veterinary medicine in the U.S. In the UK, veterinary surgeons who use homeopathy may belong to the Faculty of Homeopathy and/or to the British Association of Homeopathic Veterinary Surgeons. Animals may be treated only by qualified veterinary surgeons in the UK and some other countries. Internationally, the body that supports and represents homeopathic veterinarians is the International Association for Veterinary Homeopathy.

The use of homeopathy in veterinary medicine is controversial; the little existing research on the subject is not of a high enough scientific standard to provide reliable data on efficacy.[129][130][131] Given that homeopathy's effects in humans appear to be mainly due to the placebo effect and the counseling aspects of the consultation, it is unlikely that homeopathic treatments would be effective in animals.[132] Other studies have also found that giving animals placebos can play active roles in influencing pet owners to believe in the effectiveness of the treatment when none exists.[129] The British Veterinary Association's position statement on alternative medicines says that it "cannot endorse" homeopathy,[133] and the Australian Veterinary Association includes it on its list of "ineffective therapies".[134] A 2016 review of peer-reviewed articles from 1981 to 2014 by scientists from the University of Kassel, Germany, concluded that there was insufficient evidence to support the use of homeopathy in livestock as a way to prevent or treat infectious diseases.[135]

The UK's Department for Environment, Food and Rural Affairs (Defra) has adopted a robust position against use of "alternative" pet preparations including homeopathy.[136]
Main article: Electrohomeopathy

Electrohomeopathy is a treatment devised by Count Cesare Mattei (1809–1896), who proposed that different "colours" of electricity could be used to treat cancer. Popular in the late nineteenth century, electrohomeopathy has been described as "utter idiocy".[137]

The use of homeopathy as a preventive for serious infectious diseases is especially controversial,[138] in the context of ill-founded public alarm over the safety of vaccines stoked by the anti-vaccination movement.[139] Promotion of homeopathic alternatives to vaccines has been characterized as dangerous, inappropriate and irresponsible.[140][141] In December 2014, Australian homeopathy supplier Homeopathy Plus! were found to have acted deceptively in promoting homeopathic alternatives to vaccines.[142]
Evidence and efficacy

The low concentration of homeopathic preparations, which often lack even a single molecule of the diluted substance,[117] has been the basis of questions about the effects of the preparations since the 19th century. Modern advocates of homeopathy have proposed a concept of "water memory", according to which water "remembers" the substances mixed in it, and transmits the effect of those substances when consumed. This concept is inconsistent with the current understanding of matter, and water memory has never been demonstrated to have any detectable effect, biological or otherwise.[143][144] Pharmacological research has found instead that stronger effects of an active ingredient come from higher, not lower doses.

James Randi and the 10:23 campaign groups have highlighted the lack of active ingredients in most homeopathic products by taking large 'overdoses'.[145] None of the hundreds of demonstrators in the UK, Australia, New Zealand, Canada and the US were injured and "no one was cured of anything, either".[145][146]

Outside of the alternative medicine community, scientists have long considered homeopathy a sham[25] or a pseudoscience,[2][3][4][5] and the mainstream medical community regards it as quackery.[4] There is an overall absence of sound statistical evidence of therapeutic efficacy, which is consistent with the lack of any biologically plausible pharmacological agent or mechanism.[6]

Abstract concepts within theoretical physics have been invoked to suggest explanations of how or why preparations might work, including quantum entanglement,[147] quantum nonlocality,[148] the theory of relativity and chaos theory. Contrariwise, quantum superposition has been invoked to explain why homeopathy does not work in double-blind trials.[149] However, the explanations are offered by nonspecialists within the field, and often include speculations that are incorrect in their application of the concepts and not supported by actual experiments.[57]:255–6 Several of the key concepts of homeopathy conflict with fundamental concepts of physics and chemistry.[150] The use of quantum entanglement to explain homeopathy's purported effects is "patent nonsense", as entanglement is a delicate state that rarely lasts longer than a fraction of a second.[151] While entanglement may result in certain aspects of individual subatomic particles acquiring linked quantum states, this does not mean the particles will mirror or duplicate each other, nor cause health-improving transformations.[151]

The proposed mechanisms for homeopathy are precluded from having any effect by the laws of physics and physical chemistry.[16] The extreme dilutions used in homeopathic preparations usually leave not one molecule of the original substance in the final product.

A number of speculative mechanisms have been advanced to counter this, the most widely discussed being water memory, though this is now considered erroneous since short-range order in water only persists for about 1 picosecond.[152][153][154] No evidence of stable clusters of water molecules was found when homeopathic preparations were studied using nuclear magnetic resonance,[155] and many other physical experiments in homeopathy have been found to be of low methodological quality, which precludes any meaningful conclusion.[156] Existence of a pharmacological effect in the absence of any true active ingredient is inconsistent with the law of mass action and the observed dose-response relationships characteristic of therapeutic drugs[157] (whereas placebo effects are non-specific and unrelated to pharmacological activity[158]).

Homeopaths contend that their methods produce a therapeutically active preparation, selectively including only the intended substance, though critics note that any water will have been in contact with millions of different substances throughout its history, and homeopaths have not been able to account for a reason why only the selected homeopathic substance would be a special case in their process.[3] For comparison, ISO 3696:1987 defines a standard for water used in laboratory analysis; this allows for a contaminant level of ten parts per billion, 4C in homeopathic notation. This water may not be kept in glass as contaminants will leach out into the water.[159]

Practitioners of homeopathy hold that higher dilutions―described as being of higher potency―produce stronger medicinal effects. This idea is also inconsistent with observed dose-response relationships, where effects are dependent on the concentration of the active ingredient in the body.[157] This dose-response relationship has been confirmed in myriad experiments on organisms as diverse as nematodes,[160] rats,[161] and humans.[162] Some homeopaths contend that the phenomenon of hormesis may support the idea of dilution increasing potency,[163][164] but the dose-response relationship outside the zone of hormesis declines with dilution as normal, and nonlinear pharmacological effects do not provide any credible support for homeopathy.[165]

Physicist Robert L. Park, former executive director of the American Physical Society, is quoted as saying,

"since the least amount of a substance in a solution is one molecule, a 30C solution would have to have at least one molecule of the original substance dissolved in a minimum of 1,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000 [or 1060] molecules of water. This would require a container more than 30,000,000,000 times the size of the Earth."[166]

Park is also quoted as saying that, "to expect to get even one molecule of the 'medicinal' substance allegedly present in 30X pills, it would be necessary to take some two billion of them, which would total about a thousand tons of lactose plus whatever impurities the lactose contained".[166]

The laws of chemistry state that there is a limit to the dilution that can be made without losing the original substance altogether.[117] This limit, which is related to Avogadro's number, is roughly equal to homeopathic dilutions of 12C or 24X (1 part in 1024).[94][166][167]

Scientific tests run by both the BBC's Horizon and ABC's 20/20 programmes were unable to differentiate homeopathic dilutions from water, even when using tests suggested by homeopaths themselves.[168][169]
Old bottle of Hepar sulph made from calcium sulfide

No individual preparation has been unambiguously shown by research to be different from placebo.[6] The methodological quality of the primary research was generally low, with such problems as weaknesses in study design and reporting, small sample size, and selection bias. Since better quality trials have become available, the evidence for efficacy of homeopathy preparations has diminished; the highest-quality trials indicate that the preparations themselves exert no intrinsic effect.[19][57]:206[170] A review conducted in 2010 of all the pertinent studies of "best evidence" produced by the Cochrane Collaboration concluded that "the most reliable evidence – that produced by Cochrane reviews – fails to demonstrate that homeopathic medicines have effects beyond placebo."[171]
Government level reviews

Government-level reviews have been conducted in recent years by Switzerland (2005), the United Kingdom (2009), Australia (2015) and the European Academies' Science Advisory Council (2017).

The Swiss programme for the evaluation of complementary medicine (PEK) resulted in the peer-reviewed Shang publication (see Systematic reviews and meta-analyses of efficacy) and a controversial competing analysis[172] by homeopaths and advocates led by Gudrun Bornhöft and Peter Matthiessen, which has misleadingly been presented as a Swiss government report by homeopathy proponents, a claim that has been repudiated by the Swiss Federal Office of Public Health.[173] The Swiss Government terminated reimbursement, though it was subsequently reinstated after a political campaign and referendum for a further six-year trial period.[174]

The United Kingdom's House of Commons Science and Technology Committee sought written evidence and submissions from concerned parties[175][176] and, following a review of all submissions, concluded that there was no compelling evidence of effect other than placebo and recommended that the Medicines and Healthcare products Regulatory Agency (MHRA) should not allow homeopathic product labels to make medical claims, that homeopathic products should no longer be licensed by the MHRA, as they are not medicines, and that further clinical trials of homeopathy could not be justified.[15] They recommended that funding of homeopathic hospitals should not continue, and NHS doctors should not refer patients to homeopaths.[177] The Secretary of State for Health deferred to local NHS on funding homeopathy, in the name of patient choice.[178] By February 2011 only one-third of primary care trusts still funded homeopathy.[179] By 2012, no British universities offered homeopathy courses.[180] In July 2017, as part of a plan to save £200m a year by preventing the "misuse of scarce" funding,[181] the NHS announced that it would no longer provide homeopathic medicines.[182]

The Australian National Health and Medical Research Council completed a comprehensive review of the effectiveness of homeopathic preparations in 2015, in which it concluded that "there were no health conditions for which there was reliable evidence that homeopathy was effective. No good-quality, well-designed studies with enough participants for a meaningful result reported either that homeopathy caused greater health improvements than placebo, or caused health improvements equal to those of another treatment."[183]

On September 20, 2017, the European Academies' Science Advisory Council (EASAC) published its official analysis and conclusion on the use of homeopathic products, finding a lack of evidence that homeopathic products are effective, and raising concerns about quality control.[17]
Publication bias and other methodological issues
Further information: Statistical hypothesis testing, P-value, and Publication bias

The fact that individual randomized controlled trials have given positive results is not in contradiction with an overall lack of statistical evidence of efficacy. A small proportion of randomized controlled trials inevitably provide false-positive outcomes due to the play of chance: a "statistically significant" positive outcome is commonly adjudicated when the probability of it being due to chance rather than a real effect is no more than 5%―a level at which about 1 in 20 tests can be expected to show a positive result in the absence of any therapeutic effect.[184] Furthermore, trials of low methodological quality (i.e. ones that have been inappropriately designed, conducted or reported) are prone to give misleading results. In a systematic review of the methodological quality of randomized trials in three branches of alternative medicine, Linde et al. highlighted major weaknesses in the homeopathy sector, including poor randomization.[185] A separate 2001 systematic review that assessed the quality of clinical trials of homeopathy found that such trials were generally of lower quality than trials of conventional medicine.[186]

A related issue is publication bias: researchers are more likely to submit trials that report a positive finding for publication, and journals prefer to publish positive results.[187][188][189][190] Publication bias has been particularly marked in alternative medicine journals, where few of the published articles (just 5% during the year 2000) tend to report null results.[191] Regarding the way in which homeopathy is represented in the medical literature, a systematic review found signs of bias in the publications of clinical trials (towards negative representation in mainstream medical journals, and vice versa in alternative medicine journals), but not in reviews.[19]

Positive results are much more likely to be false if the prior probability of the claim under test is low.[190]
Systematic reviews and meta-analyses of efficacy

Both meta-analyses, which statistically combine the results of several randomized controlled trials, and other systematic reviews of the literature are essential tools to summarize evidence of therapeutic efficacy.[192] Early systematic reviews and meta-analyses of trials evaluating the efficacy of homeopathic preparations in comparison with placebo more often tended to generate positive results, but appeared unconvincing overall.[193] In particular, reports of three large meta-analyses warned readers that firm conclusions could not be reached, largely due to methodological flaws in the primary studies and the difficulty in controlling for publication bias.[18][22][194] The positive finding of one of the most prominent of the early meta-analyses, published in The Lancet in 1997 by Linde et al.,[194] was later reframed by the same research team, who wrote:

The evidence of bias [in the primary studies] weakens the findings of our original meta-analysis. Since we completed our literature search in 1995, a considerable number of new homeopathy trials have been published. The fact that a number of the new high-quality trials ... have negative results, and a recent update of our review for the most "original" subtype of homeopathy (classical or individualized homeopathy), seem to confirm the finding that more rigorous trials have less-promising results. It seems, therefore, likely that our meta-analysis at least overestimated the effects of homeopathic treatments.[170]

Subsequent work by John Ioannidis and others has shown that for treatments with no prior plausibility, the chances of a positive homeopatska medicina result being a false positive are much higher, and that any result not consistent with the null hypothesis should be assumed to be a false positive.[190][195]

In 2002, a systematic review of the available systematic reviews confirmed that higher-quality trials tended to have less positive results, and found no convincing evidence that any homeopathic preparation exerts clinical effects different from placebo.[6]

In 2005, The Lancet medical journal published a meta-analysis of 110 placebo-controlled homeopathy trials and 110 matched medical trials based upon the Swiss government's Programme for Evaluating Complementary Medicine, or PEK. The study concluded that its findings were "compatible with the notion that the clinical effects of homeopathy are placebo effects".[7] This was accompanied by an editorial pronouncing "The end of homoeopathy",[196] which was denounced by the homeopath Peter Fisher.[197]

Other meta-analyses include homeopathic treatments to reduce cancer therapy side-effects following radiotherapy and chemotherapy,[198] allergic rhinitis,[199][200] attention-deficit hyperactivity disorder and childhood diarrhoea, adenoid vegetation, asthma, upper respiratory tract infection in children,[201] insomnia,[202] fibromyalgia,[203] psychiatric conditions[204] and Cochrane Library reviews of homeopathic treatments for asthma,[205] dementia,[206] attention-deficit hyperactivity disorder,[207] induction of labour,[208] and irritable bowel syndrome.[209] Other reviews covered osteoarthritis,[210] migraines,[211] postoperative ecchymosis and edema,[212] delayed-onset muscle soreness,[70] preventing postpartum haemorrhage,[213] or eczema[214] and other dermatological conditions.[215]

A 2017 systematic review and meta-analysis found that the most reliable evidence did not support the effectiveness of non-individualized homeopathy. The authors noted that "the quality of the body of evidence is low."[216]

The results of these reviews are generally negative or only weakly positive, and reviewers consistently report the poor quality of trials. The finding of Linde et. al. that more rigorous studies produce less positive results is supported in several and contradicted by none.

Some clinical trials have tested individualized homeopathy, and there have been reviews of this, specifically. A 1998 review[217] found 32 trials that met their inclusion criteria, 19 of which were placebo-controlled and provided enough data for meta-analysis. These 19 studies showed a pooled odds ratio of 1.17 to 2.23 in favour of individualized homeopathy over the placebo, but no difference was seen when the analysis was restricted to the methodologically best trials. The authors concluded that "the results of the available randomized trials suggest that individualized homeopathy has an effect over placebo. The evidence, however, is not convincing because of methodological shortcomings and inconsistencies." Jay Shelton, author of a book on homeopathy, has stated that the claim assumes without evidence that classical, individualized homeopathy works better than nonclassical variations.[57]:209 A 2014 systematic review and meta-analysis found that individualized homeopathic remedies may be slightly more effective than placebos, though the authors noted that their findings were based on low- or unclear-quality evidence.[218] The same research team later reported that taking into account model validity did not significantly affect this conclusion.[219]
Statements by major medical organizations
A homeopathic preparation made from potassium dichromate, the chemical compound well known for its toxic and carcinogenic properties

Health organizations such as the UK's National Health Service,[220] the American Medical Association,[221] the FASEB,[154] and the National Health and Medical Research Council of Australia,[183] have issued statements of their conclusion that there is "no good-quality evidence that homeopathy is effective as a treatment for any health condition".[220] In 2009, World Health Organization official Mario Raviglione criticized the use of homeopathy to treat tuberculosis; similarly, another WHO spokesperson argued there was no evidence homeopathy would be an effective treatment for diarrhoea.[222]

The American College of Medical Toxicology and the American Academy of Clinical Toxicology recommend that no one use homeopathic treatment for disease or as a preventive health measure.[223] These organizations report that no evidence exists that homeopathic treatment is effective, but that there is evidence that using these treatments produces harm and can bring indirect health risks by delaying conventional treatment.[223]
Explanations of perceived effects

Science offers a variety of explanations for how homeopathy may appear to cure diseases or alleviate symptoms even though the preparations themselves are inert:[57]:155–167

The placebo effect – the intensive consultation process and expectations for the homeopathic preparations may cause the effect.
Therapeutic effect of the consultation – the care, concern, and reassurance a patient experiences when opening up to a compassionate caregiver can have a positive effect on the patient's well-being.[224]
Unassisted natural healing – time and the body's ability to heal without assistance can eliminate many diseases of their own accord.
Unrecognized treatments – an unrelated food, exercise, environmental agent, or treatment for a different ailment, may have occurred.
Regression towards the mean – since many diseases or conditions are cyclical, symptoms vary over time and patients tend to seek care when discomfort is greatest; they may feel better anyway but because of the timing of the visit to the homeopath they attribute improvement to the preparation taken.
Non-homeopathic treatment – patients may also receive standard medical care at the same time as homeopathic treatment, and the former is responsible for improvement.
Cessation of unpleasant treatment – often homeopaths recommend patients stop getting medical treatment such as surgery or drugs, which can cause unpleasant side-effects; improvements are attributed to homeopathy when the actual cause is the cessation of the treatment causing side-effects in the first place, but the underlying disease remains untreated and still dangerous to the patient.

Purported effects in other biological systems
Old homeopathic belladonna preparation.

While some articles have suggested that homeopathic solutions of high dilution can have statistically significant effects on organic processes including the growth of grain,[225] histamine release by leukocytes,[226] and enzyme reactions, such evidence is disputed since attempts to replicate them have failed.[227][228][229][230][231][232] A 2007 systematic review of high-dilution experiments found that none of the experiments with positive results could be reproduced by all investigators.[233]

In 1987, French immunologist Jacques Benveniste submitted a paper to the journal Nature while working at INSERM. The paper purported to have discovered that basophils, a type of white blood cell, released histamine when exposed to a homeopathic dilution of anti-immunoglobulin E antibody. The journal editors, sceptical of the results, requested that the study be replicated in a separate laboratory. Upon replication in four separate laboratories the study was published. Still sceptical of the findings, Nature assembled an independent investigative team to determine the accuracy of the research, consisting of Nature editor and physicist Sir John Maddox, American scientific fraud investigator and chemist Walter Stewart, and sceptic James Randi. After investigating the findings and methodology of the experiment, the team found that the experiments were "statistically ill-controlled", "interpretation has been clouded by the exclusion of measurements in conflict with the claim", and concluded, "We believe that experimental data have been uncritically assessed and their imperfections inadequately reported."[144][234][235] James Randi stated that he doubted that there had been any conscious fraud, but that the researchers had allowed "wishful thinking" to influence their interpretation of the data.[234]

In 2001 and 2004, Madeleine Ennis published a number of studies that reported that homeopathic dilutions of histamine exerted an effect on the activity of basophils.[236][237] In response to the first of these studies, Horizon aired a programme in which British scientists attempted to replicate Ennis' results; they were unable to do so.[238]
Ethics and safety

The provision of homeopathic preparations has been described as unethical.[20] Michael Baum, Professor Emeritus of Surgery and visiting Professor of Medical Humanities at University College London (UCL), has described homoeopathy as a "cruel deception".[239]

Edzard Ernst, the first Professor of Complementary Medicine in the United Kingdom and a former homeopathic practitioner,[240][241][242] has expressed his concerns about pharmacists who violate their ethical code by failing to provide customers with "necessary and relevant information" about the true nature of the homeopathic products they advertise and sell:

"My plea is simply for honesty. Let people buy what they want, but tell them the truth about what they are buying. These treatments are biologically implausible and the clinical tests have shown they don't do anything at all in human beings. The argument that this information is not relevant or important for customers is quite simply ridiculous."[243]

Patients who choose to use homeopathy rather than evidence-based medicine risk missing timely diagnosis and effective treatment of serious conditions such as cancer.[201][244]

In 2013 the UK Advertising Standards Authority concluded that the Society of Homeopaths were targeting vulnerable ill people and discouraging the use of essential medical treatment while making misleading claims of efficacy for homeopathic products.[245]

In 2015 the Federal Court of Australia imposed penalties on a homeopathic company, Homeopathy Plus! Pty Ltd and its director, for making false or misleading statements about the efficacy of the whooping cough vaccine and homeopathic remedies as an alternative to the whooping cough vaccine, in breach of the Australian Consumer Law.[246]
Adverse effects

Some homeopathic preparations involve poisons such as Belladonna, arsenic, and poison ivy, which are highly diluted in the homeopathic preparation. In rare cases, the original ingredients are present at detectable levels. This may be due to improper preparation or intentional low dilution. Serious adverse effects such as seizures and death have been reported or associated with some homeopathic preparations.[247][248]

On September 30, 2016 the FDA issued a safety alert to consumers[249] warning against the use of homeopathic teething gels and tablets following reports of adverse events after their use. The agency recommended that parents discard these products and "seek advice from their health care professional for safe alternatives"[250] to homeopathy for teething. The pharmacy CVS announced, also on September 30, that it was voluntarily withdrawing the products from sale[251] and on October 11 Hyland's (the manufacturer) announced that it was discontinuing their teething medicine in the United States[252] though the products remain on sale in Canada.[253] On October 12, Buzzfeed reported that the regulator had "examined more than 400 reports of seizures, fever and vomiting, as well as 10 deaths" over a six-year period. The investigation (including analyses of the products) is still ongoing and the FDA does not know yet if the deaths and illnesses were caused by the products.[254] However a previous FDA investigation in 2010, following adverse effects reported then, found that these same products were improperly diluted and contained "unsafe levels of belladonna, also known as deadly nightshade" and that the reports of serious adverse events in children using this product were "consistent with belladonna toxicity".[255]

Instances of arsenic poisoning have occurred after use of arsenic-containing homeopathic preparations.[256] Zicam Cold remedy Nasal Gel, which contains 2X (1:100) zinc gluconate, reportedly caused a small percentage of users to lose their sense of smell;[257] 340 cases were settled out of court in 2006 for 12 million U.S. dollars.[258] In 2009, the FDA advised consumers to stop using three discontinued cold remedy Zicam products because it could cause permanent damage to users' sense of smell.[259] Zicam was launched without a New Drug Application (NDA) under a provision in the FDA's Compliance Policy Guide called "Conditions under which homeopathic drugs may be marketed" (CPG 7132.15), but the FDA warned Matrixx Initiatives, its manufacturer, via a Warning Letter that this policy does not apply when there is a health risk to consumers.[260]

A 2000 review by homeopaths reported that homeopathic preparations are "unlikely to provoke severe adverse reactions".[261] In 2012, a systematic review evaluating evidence of homeopathy's possible adverse effects concluded that "homeopathy has the potential to harm patients and consumers in both direct and indirect ways".[247] One of the reviewers, Edzard Ernst, supplemented the article on his blog, writing: "I have said it often and I say it again: if used as an alternative to an effective cure, even the most 'harmless' treatment can become life-threatening."[262] A 2016 systematic review and meta-analysis found that, in homeopathic clinical trials, adverse effects were reported among the patients who received homeopathy about as often as they were reported among patients who received placebo or conventional medicine.[263]
Lack of efficacy

The lack of convincing scientific evidence supporting its efficacy[264] and its use of preparations without active ingredients have led to characterizations as pseudoscience and quackery,[265][266][267][268][269][270] or, in the words of a 1998 medical review, "placebo therapy at best and quackery at worst".[271] The Russian Academy of Sciences considers homeopathy a "dangerous 'pseudoscience' that does not work", and "urges people to treat homeopathy 'on a par with magic'".[265][266] The Chief Medical Officer for England, Dame Sally Davies, has stated that homeopathic preparations are "rubbish" and do not serve as anything more than placebos.[272] Jack Killen, acting deputy director of the National Center for Complementary and Alternative Medicine, says homeopathy "goes beyond current understanding of chemistry and physics". He adds: "There is, to my knowledge, no condition for which homeopathy has been proven to be an effective treatment."[264] Ben Goldacre says that homeopaths who misrepresent scientific evidence to a scientifically illiterate public, have "... walled themselves off from academic medicine, and critique has been all too often met with avoidance rather than argument".[191] Homeopaths often prefer to ignore meta-analyses in favour of cherry picked positive results, such as by promoting a particular observational study (one which Goldacre describes as "little more than a customer-satisfaction survey") as if it were more informative than a series of randomized controlled trials.[191]

Referring specifically to homeopathy, the British House of Commons Science and Technology Committee has stated:

In our view, the systematic reviews and meta-analyses conclusively demonstrate that homeopathic products perform no better than placebos. The Government shares our interpretation of the evidence.[8]

In the Committee's view, homeopathy is a placebo treatment and the Government should have a policy on prescribing placebos. The Government is reluctant to address the appropriateness and ethics of prescribing placebos to patients, which usually relies on some degree of patient deception. Prescribing of placebos is not consistent with an informed patient choice - which the Government claims is very important - as it means patients do not have all the information needed to make choice meaningful.

Beyond ethical issues and the integrity of the doctor-patient relationship, prescribing pure placebos is bad medicine. Their effect is unreliable and unpredictable and cannot form the sole basis of any treatment on the NHS.[15]

The National Center for Complementary and Alternative Medicine of the United States' National Institutes of Health states:

Homeopathy is a controversial topic in complementary medicine research. A number of the key concepts of homeopathy are not consistent with fundamental concepts of chemistry and physics. For example, it is not possible to explain in scientific terms how a preparation containing little or no active ingredient can have any effect. This, in turn, creates major challenges to the rigorous clinical investigation of homeopathic preparations. For example, one cannot confirm that an extremely dilute preparation contains what is listed on the label, or develop objective measures that show effects of extremely dilute preparations in the human body.[273]

Ben Goldacre noted that in the early days of homeopathy, when medicine was dogmatic and frequently worse than doing nothing, homeopathy at least failed to make matters worse:

During the 19th-century cholera epidemic, death rates at the London Homeopathic Hospital were three times lower than at the Middlesex Hospital. Homeopathic sugar pills won't do anything against cholera, of course, but the reason for homeopathy's success in this epidemic is even more interesting than the placebo effect: at the time, nobody could treat cholera. So, while hideous medical treatments such as blood-letting were actively harmful, the homeopaths' treatments at least did nothing either way.[274]

In lieu of standard medical treatment

On clinical grounds, patients who choose to use homeopathy in preference to normal medicine risk missing timely diagnosis and effective treatment, thereby worsening the outcomes of serious conditions.[201][244][275][276] Critics of homeopathy have cited individual cases of patients of homeopathy failing to receive proper treatment for diseases that could have been easily diagnosed and managed with conventional medicine and who have died as a result,[277][278] and the "marketing practice" of criticizing and downplaying the effectiveness of mainstream medicine.[191][278] Homeopaths claim that use of conventional medicines will "push the disease deeper" and cause more serious conditions, a process referred to as "suppression".[279] Some homeopaths (particularly those who are non-physicians) advise their patients against immunization.[275][280][281] Some homeopaths suggest that vaccines be replaced with homeopathic "nosodes", created from biological materials such as pus, diseased tissue, bacilli from sputum or (in the case of "bowel nosodes") faeces.[282] While Hahnemann was opposed to such preparations, modern homeopaths often use them although there is no evidence to indicate they have any beneficial effects.[283][284] Cases of homeopaths advising against the use of anti-malarial drugs have been identified.[276][285][286] This puts visitors to the tropics who take this advice in severe danger, since homeopathic preparations are completely ineffective against the malaria parasite.[276][285][286][287] Also, in one case in 2004, a homeopath instructed one of her patients to stop taking conventional medication for a heart condition, advising her on June 22, 2004 to "Stop ALL medications including homeopathic", advising her on or around August 20 that she no longer needed to take her heart medication, and adding on August 23, "She just cannot take ANY drugs – I have suggested some homeopathic remedies ... I feel confident that if she follows the advice she will regain her health." The patient was admitted to hospital the next day, a

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